Table 3.
Yeast gene(s)a | Human ortholog | Human protein |
---|---|---|
BAP2 | SLC7A1 | Cationic amino acid transport permease |
BCY1 | PRKAR2A | cAMP-dependent protein kinase regulatory subunit |
FBP26/PFK26 | PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
GCN2 | EIF2AK4 | Eukaryotic translation initiation factor 2-alpha kinase |
GPB1/2 | ETEA | Functional ortholog of GPB1/2; inhibits neurofibromin 1 |
IRA2 | NF1 | Neurofibromin 1, tumor suppressor protein |
LAT1 | DLAT | Dihydrolipoamide acetyltransferase component of PDH complex |
LPD1 | DLD | Dihydrolipoamide dehydrogenase component of PDH complex |
NPR2 | NPRL2 | Nitrogen permease regulator-like 2, tumor suppressor candidate |
PDB1 | PDHB | PDH, E1 component |
PDX1 | PDHX | Anchors DLD to the DLAT core in the PDH complex |
RAS2 | KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
RMD5 | RMND5A | Required for meiotic nuclear division 5 Saccharomyces cerevisiae homolog |
VID30 | RANBP10 | Ran-binding protein 10 |
aDeletion of any of these genes caused sensitivity to dieldrin (listed in alphabetical order).