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. 2013 Jan 28;132(2):347–358. doi: 10.1093/toxsci/kft018

Table 3.

Selected Yeast Genes Required for Dieldrin Tolerance and Their Human Orthologs

Yeast gene(s)a Human ortholog Human protein
BAP2 SLC7A1 Cationic amino acid transport permease
BCY1 PRKAR2A cAMP-dependent protein kinase regulatory subunit
FBP26/PFK26 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
GCN2 EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase
GPB1/2 ETEA Functional ortholog of GPB1/2; inhibits neurofibromin 1
IRA2 NF1 Neurofibromin 1, tumor suppressor protein
LAT1 DLAT Dihydrolipoamide acetyltransferase component of PDH complex
LPD1 DLD Dihydrolipoamide dehydrogenase component of PDH complex
NPR2 NPRL2 Nitrogen permease regulator-like 2, tumor suppressor candidate
PDB1 PDHB PDH, E1 component
PDX1 PDHX Anchors DLD to the DLAT core in the PDH complex
RAS2 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RMD5 RMND5A Required for meiotic nuclear division 5 Saccharomyces cerevisiae homolog
VID30 RANBP10 Ran-binding protein 10

aDeletion of any of these genes caused sensitivity to dieldrin (listed in alphabetical order).