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. Author manuscript; available in PMC: 2013 Aug 10.
Published in final edited form as: Mol Cell. 2012 Jun 14;47(3):339–348. doi: 10.1016/j.molcel.2012.05.027

Figure 2. The PROPPIN family has two conserved lipid binding sites.

Figure 2

  1. Structurally annotated alignment of PROPPIN sequences for lipid-binding blades 5 and 6. Sequences were aligned with T-Coffee within each blade based on multiple alignment of primary sequences. Residues showing 100, 80 and 60% conservation across the different proteins are highlighted in red, blue and green respectively.
  2. Ribbon representation of the structural superposition of blades 5 (green) and 6 (pink). The sulfates and binding sites residues are shown in ball and stick model.
  3. Mutations in the indicated site 1 and site 2 residues reduce or eliminate binding to liposomes.