Fig. 4.

Chronic AY9944 treatment results in no significant changes in chain lengths of rat liver dolichols, compared to controls. Dolichol isoprene species identification and quantification by HPLC. The panels denote representative reversed phase (C18) HPLC chromatograms monitored at 210 nm for dolichols of increasing isoprene chain lengths from a control rat liver (black line) with dolichol standards (gray line) and b AY9944-treated rat liver (black line) with dolichol standards (gray line). c Relative amounts of liver dolichol species of varying isoprene chain lengths from control (gray bars) and AY9944-treated (black bars) rats as determined empirically from integration of the HPLC chromatograms in (a) and (b). Values represent mean ± S.D. (N = 4)