Table 1.

Effect of AY9944 treatment on the steady-state levels of sterols and squalene in rat (a) liver and (b) serum

Tissue/treatment	Cholesterol (μg g−1)	7DHC (μg g−1)	Squalene (μg g−1)	Chol + DHC (μg g−1)	Percent of control
(a) Liver*
Control	1,819 ± 141	5.6 ± 0.7	29.2 ± 1.8	1,825 ± 141	100
AY9944	78 ± 11a	2,529 ± 163a	18.1 ± 3.0b	2,607 ± 161a	143a
(b) Serum#
Control	105.5 ± 6.8	0.17 ± 0.09	0.029 ± 0.007	105.6 ± 6.9	100
AY9944	1.1 ± 0.4a	16.6 ± 2.8a	0.027 ± 0.011c	17.6 ± 3.2a	16a

Values are mean ± SD (N = 6), as determined by reversed-phase HPLC (corrected for recovery efficiency)

^*Values expressed as μg per gram wet weight of liver

^# Values expressed as mg per dl of serum

^ap < 0.001,

^bp < 0.05,

^cnot significant