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. 2013 Jan 29;14(3):752–760. doi: 10.1021/bm3018356

Figure 4.

Figure 4

Real-time biodistribution of Cy5.5-labeled siRNA and nanoplexes. (A) Representative biodistribution of Cy5.5-labeled siRNA in a mouse, with the siRNA administered as an aqueous solution, unmodified HK nanoplex or RP-HK nanoplex. Times 15, 30, 60, 120 min, and 4, 6, and 24 h are shown. Red circles encircle the tumors. (B) Fluorescence emission localized at the tumor was measured for the different siRNA groups. The data represent the mean ± SD of fluorescence of four determinations for each carrier. *, P < 0.05; **, P < 0.01; RP-HK carrier versus unmodified HK carriers and control groups.