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PEG and RGD modifications of HK enhance gene silencing in tumor xenografts. Luciferase siRNA nanoplexes with unmodified, PEG or RGD-PEG (RP) modified H3K(+H)4b were systemically administered to tumor xenografts bearing mice. Before and 48 h after treatment, luciferase activity was determined by an IVIS 200 system. The data represent the mean ± SD of luciferase of four determinations for each carrier. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
