. 2013 Jan 29;14(3):752–760. doi: 10.1021/bm3018356

Table 2. Pharmacokinetic Parameters for siRNA Formulations.

	t_1/2β^a (min)	CL^b(mL/min/kg)	AUC_2h^c (μg/mL × min)	MRT^d (min)
aqueous siRNA	27.7	18.50	126.3 ± 52.7	41.4
H3K(+H)4b:siRNA	86.6	16.62	98.0 ± 58.6	129.5
RP-HK:siRNA	256.7	1.57	385.0 ± 92.4	374.7

t_1/2β, terminal half-life.

CL, clearance.

AUC_2h, area under curve from 0 to 2 h.

MRT, mean residence time.