Table 2.
Genetic loci associated with the occurrence of ACL with P < 1E − 04*.
| CHR | Gene | Lead SNP | BP | Total SNPs | MAF | OR | P | |
|---|---|---|---|---|---|---|---|---|
| Negative | Positive | |||||||
| 5 | PELO | rs6889746 | 51742663 | 3 | 0.3534 | 0.5 | 1.776 | 6.02E − 06 |
| 1 | SGIP1 | rs6681460 | 66895645 | 28 | 0.3755 | 0.5168 | 1.827 | 6.98E − 06 |
| 6 | LCA5 | rs12204683 | 80212978 | 4 | 0.2378 | 0.3701 | 1.877 | 7.02E − 06 |
| 4 | MIR4275 | rs17642174 | 28160435 | 6 | 0.1355 | 0.2346 | 2.021 | 1.42E − 05 |
| 4 | C4orf37 | rs13134014 | 99323902 | 21 | 0.1517 | 0.2542 | 1.928 | 1.76E − 05 |
| 7 | BZW2 | rs6961256 | 16697717 | 3 | 0.01261 | 0.05587 | 5.214 | 1.96E − 05 |
| 2 | FAM49A | rs6753768 | 16483918 | 11 | 0.2836 | 0.1648 | 0.5016 | 2.37E − 05 |
| 4 | MAD2L1 | rs10518344 | 1.21E + 08 | 3 | 0.05136 | 0.1178 | 2.696 | 2.77E − 05 |
| 11 | KIRREL3 | rs1793667 | 1.26E + 08 | 1 | 0.2789 | 0.3966 | 1.781 | 2.89E − 05 |
| 14 | YLPM1 | rs2241275 | 74321193 | 7 | 0.435 | 0.5587 | 1.754 | 3.06E − 05 |
| 14 | PROX2 | rs4899536 | 74386367 | 2 | 0.4331 | 0.5559 | 1.752 | 3.28E − 05 |
| 2 | ATL2 | rs6749177 | 38531205 | 11 | 0.4958 | 0.3659 | 0.576 | 3.77E − 05 |
| 17 | PRPSAP1 | rs11077813 | 71848140 | 1 | 0.2704 | 0.1564 | 0.5072 | 3.82E − 05 |
| 9 | TTLL11 | rs10985483 | 1.24E + 08 | 4 | 0.3703 | 0.25 | 0.5571 | 4.09E − 05 |
| 8 | ZBTB10 | rs406629 | 81620942 | 6 | 0.3795 | 0.2599 | 0.5501 | 4.26E − 05 |
| 21 | LINC00317 | rs2827107 | 22175926 | 3 | 0.2128 | 0.3156 | 1.847 | 5.63E − 05 |
| 7 | NUPL2 | rs10232205 | 23197079 | 1 | 0.09244 | 0.02793 | 0.2465 | 6.22E − 05 |
| 1 | DUSP10 | rs11118750 | 2.2E + 08 | 4 | 0.2174 | 0.3287 | 1.753 | 6.88E − 05 |
| 15 | MCTP2 | rs1863095 | 92917093 | 1 | 0.3224 | 0.4511 | 1.665 | 6.90E − 05 |
| 17 | SHPK | rs222790 | 3478239 | 1 | 0.2051 | 0.3097 | 1.793 | 7.30E − 05 |
| 6 | KHDRBS2 | rs2752976 | 63486388 | 11 | 0.431 | 0.5447 | 1.688 | 7.88E − 05 |
| 5 | GLRA1 | rs154111 | 1.51E + 08 | 14 | 0.4569 | 0.3399 | 0.5875 | 7.91E − 05 |
| 9 | MIR548AA1 | rs4836873 | 1.24E + 08 | 4 | 0.3651 | 0.2514 | 0.5746 | 8.29E − 05 |
| 1 | LOC100505918 | rs16860501 | 1.67E + 08 | 1 | 0.09119 | 0.1648 | 2.116 | 8.89E − 05 |
| 19 | OR7A10 | rs4808564 | 14825095 | 1 | 0.05126 | 0.1117 | 2.449 | 8.91E − 05 |
| 9 | C9orf46 | rs4742085 | 5340548 | 2 | 0.3501 | 0.4678 | 1.696 | 9.02E − 05 |
| 9 | PTPRD | rs2484741 | 10477877 | 7 | 0.2977 | 0.1983 | 0.5439 | 9.79E − 05 |
| 16 | PDXDC1 | rs3198697 | 15037441 | 1 | 0.3658 | 0.4859 | 1.646 | 9.83E − 05 |
*CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with P < 1E − 03 in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; P: P-values for the test.