Table 4.
Genetic loci associated with the occurrence of anti-β 2GPI antibodies with P < 1E − 04*.
| CHR | Gene | Lead SNP | BP | Total SNPs | MAF | OR | P | |
|---|---|---|---|---|---|---|---|---|
| Negative | Positive | |||||||
| 13 | MYO16 | rs10492418 | 108178727 | 5 | 0.4292 | 0.6016 | 2.172 | 2.05E − 06 |
| 7 | PDE1C | rs11975235 | 32156065 | 4 | 0.4843 | 0.311 | 0.4675 | 2.88E − 06 |
| 2 | TANK | rs2357982 | 161594349 | 13 | 0.2359 | 0.3885 | 2.189 | 3.38E − 06 |
| 13 | FLJ42392 | rs9315762 | 39639907 | 2 | 0.1535 | 0.2901 | 2.255 | 6.68E − 06 |
| 20 | MACROD2 | rs6080100 | 15951406 | 7 | 0.2655 | 0.4275 | 2.086 | 6.86E − 06 |
| 17 | CAMKK1 | rs758642 | 3733656 | 1 | 0.3314 | 0.4837 | 2.038 | 1.23E − 05 |
| 14 | ITPK1 | rs8021497 | 92637371 | 6 | 0.2059 | 0.3508 | 2.101 | 1.26E − 05 |
| 2 | SESTD1 | rs10186547 | 179921914 | 2 | 0.3853 | 0.5391 | 2.009 | 1.56E − 05 |
| 10 | CACNB2 | rs12356676 | 18687510 | 6 | 0.2587 | 0.3943 | 2.134 | 1.80E − 05 |
| 18 | LRRC30 | rs9965173 | 7201755 | 4 | 0.07887 | 0.1718 | 2.647 | 2.59E − 05 |
| 3 | PEX5L | rs9856007 | 181225431 | 3 | 0.2514 | 0.3817 | 1.976 | 3.68E − 05 |
| 11 | TMEM45B | rs10894119 | 129081436 | 1 | 0.1835 | 0.293 | 2.168 | 4.05E − 05 |
| 10 | SFTA1P | rs1000039 | 10597879 | 1 | 0.02254 | 0.08779 | 4.19 | 4.13E − 05 |
| 9 | OR1J1 | rs2778636 | 124270913 | 2 | 0.2641 | 0.3931 | 1.955 | 4.43E − 05 |
| 5 | RAPGEF6 | rs17671387 | 130911895 | 1 | 0.04507 | 0.1183 | 3.186 | 4.71E − 05 |
| 2 | GMCL1 | rs4241261 | 69917164 | 3 | 0.4761 | 0.3308 | 0.5278 | 4.93E − 05 |
| 14 | C14orf101 | rs7153196 | 56256660 | 2 | 0.362 | 0.229 | 0.4996 | 5.58E − 05 |
| 9 | WNK2 | rs10821084 | 94991443 | 1 | 0.07627 | 0.1718 | 2.425 | 6.33E − 05 |
| 10 | SLC16A9 | rs7082987 | 61007793 | 1 | 0.3663 | 0.2317 | 0.4886 | 6.46E − 05 |
| 4 | GDEP | rs11730315 | 81020089 | 2 | 0.1648 | 0.2829 | 2.075 | 7.24E − 05 |
| 4 | ARHGAP24 | rs17010960 | 86938938 | 2 | 0.02254 | 0.07634 | 4.326 | 7.85E − 05 |
| 13 | HTR2A | rs582385 | 46343995 | 4 | 0.1624 | 0.2824 | 2.02 | 8.09E − 05 |
| 15 | FMN1 | rs2444955 | 31199305 | 2 | 0.2211 | 0.355 | 1.974 | 8.10E − 05 |
| 5 | CARTPT | rs16869487 | 70976850 | 1 | 0.02841 | 0.09542 | 3.602 | 8.59E − 05 |
| 2 | NEU2 | rs11695991 | 233608333 | 1 | 0.0169 | 0.0687 | 4.802 | 8.63E − 05 |
| 17 | CA10 | rs203076 | 47354484 | 7 | 0.2944 | 0.1603 | 0.4729 | 8.70E − 05 |
| 9 | C9orf135 | rs1389124 | 71669176 | 3 | 0.09943 | 0.1985 | 2.286 | 9.23E − 05 |
| 20 | SMOX | rs1764996 | 4070805 | 2 | 0.02817 | 0.07634 | 4.014 | 9.93E − 05 |
*CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with P < 1E − 03 in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; P: P-values for the test.