Table 5.

Genetic loci associated with the occurrence of two or more antiphospholipid antibodies (ACL, LAC, or Anti-β ₂GPI) with P < 1E − 04*.

CHR	Gene	Lead SNP	BP	Total SNPs	MAF		OR	P
					Negative	Positive
16	DYNLRB2	rs8060581	78750106	6	0.02466	0.1406	6.714	1.44E − 06
2	SESTD1	rs13403289	179924976	2	0.3857	0.5833	2.423	6.08E − 06
1	DNAH14	rs3913653	223603694	11	0.543	0.3421	0.43	1.09E − 05
10	CACNB2	rs10828616	18710023	6	0.2175	0.3698	2.538	1.11E − 05
18	EPB41L3	rs7238186	5469093	2	0.213	0.3854	2.327	2.61E − 05
1	MAGI3	rs11102625	113750976	5	0.4355	0.6146	2.298	2.75E − 05
2	TANK	rs13010671	161593338	5	0.07442	0.1882	3.437	3.17E − 05
7	CNTNAP2	rs12113442	145329124	1	0.1054	0.2188	2.938	3.43E − 05
18	ZNF519	rs8093228	13989380	4	0.2152	0.3646	2.326	4.85E − 05
3	FAM198A	rs7624799	43020807	3	0.1592	0.2969	2.466	5.00E − 05
20	DSTN	rs17791782	17514069	2	0.07883	0.1927	3.086	5.06E − 05
20	BFSP1	rs16999416	17489830	1	0.08371	0.2031	2.93	5.63E − 05
13	ANKRD20A9P	rs7319595	18392986	1	0.3484	0.5213	2.337	5.75E − 05
15	TLE3	rs10518889	68337482	4	0.2838	0.4427	2.231	6.17E − 05
22	CLTCL1	rs8135222	17672446	1	0.1749	0.3281	2.293	6.19E − 05
11	TMEM45B	rs10894119	129081436	1	0.1789	0.3158	2.432	6.25E − 05
1	GADD45A	rs787480	67868460	1	0.2207	0.08854	0.3088	6.57E − 05
20	SPTLC3	rs6105044	13065747	2	0.352	0.1979	0.4138	7.08E − 05
6	HIVEP1	rs6908010	12325985	2	0.4753	0.3073	0.4688	7.11E − 05
7	CUX1	rs427534	101673424	3	0.4439	0.2656	0.4569	7.28E − 05
10	MSMB	rs7094791	51229942	1	0.3857	0.2396	0.4081	7.35E − 05
8	TPD52	rs10090469	81396522	1	0.1099	0.2292	2.668	7.43E − 05
14	LOC100506433	rs698322	47597316	1	0.3914	0.2344	0.4277	7.58E − 05
6	MMS22L	rs1206164	97703068	1	0.2511	0.4219	2.212	8.26E − 05
12	CDK17	rs11108526	95379901	2	0.02691	0.08333	5.95	8.40E − 05
11	PDGFD	rs4754095	103278377	3	0.2851	0.1436	0.3771	8.83E − 05
15	FMN1	rs2444955	31199305	2	0.1951	0.3474	2.408	8.89E − 05
10	SORCS1	rs4918273	108715485	11	0.3597	0.5319	2.064	8.92E − 05

*CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with P < 1E − 03 in the gene region; MAF: minor allele frequencies in antibody-negative (negative for ALC, ACL and anti-β ₂GPI) and antibody-positive (positive for at least two of ALC, ACL or anti-β ₂GPI) groups; OR: odds ratio; P: P-values for the test.