Table 6.
Significant SNPs with P < 0.01 in the MHC region on chromosome 6 for ACL, LAC, and Anti-β 2GP1*.
| Gene | SNP | P |
|---|---|---|
| ACL | ||
|
| ||
| HLA-DPB1 | rs3128918 | 0.00028 |
| HLA-DPB2 | rs2395357 | 0.00043 |
| HLA-DMA | rs11539216 | 0.00099 |
| HLA-DQB2 | rs10484564 | 0.00536 |
| GNL1 | rs9295888 | 0.00758 |
| GNL1 | rs9295873 | 0.00794 |
| HLA-DOA | rs4713603 | 0.0081 |
| RPP21 | rs1548515 | 0.00842 |
| GNL1 | rs9461607 | 0.00863 |
| GNL1 | rs17411480 | 0.00863 |
| RPP21 | rs9261821 | 0.00863 |
| RPP21 | rs9261850 | 0.00863 |
| RPP21 | rs9261854 | 0.00863 |
| RPP21 | rs9261855 | 0.00863 |
| RPP21 | rs1548513 | 0.00863 |
| RPP21 | rs9261925 | 0.00863 |
| RPP21 | rs9261926 | 0.00863 |
| BRD2 | rs17840186 | 0.00939 |
| RPP21 | rs9261799 | 0.00955 |
|
| ||
| LAC | ||
|
| ||
| TAP2 | rs1044043 | 0.00029 |
| HLA-DQA1 | rs642093 | 0.00032 |
| AIF1 | rs2736177 | 0.00041 |
| HLA-DQA2 | rs9275765 | 0.00078 |
| HLA-DQA2 | rs9275772 | 0.00078 |
| HLA-DQA2 | rs9275793 | 0.00088 |
| HLA-DQA1 | rs9272346 | 0.00130 |
| HLA-DQA2 | rs9276298 | 0.00133 |
| HLA-DQA1 | rs9272219 | 0.00167 |
| C6orf10 | rs3129934 | 0.00168 |
| HLA-DQA1 | rs9272535 | 0.00179 |
| HLA-DRB1 | rs674313 | 0.00215 |
| HLA-DRB1 | rs502771 | 0.00227 |
| HLA-DRB1 | rs9270986 | 0.00250 |
| AIF1 | rs2857597 | 0.00257 |
| HCG26 | rs2516516 | 0.00282 |
| HLA-DRB1 | rs615672 | 0.00295 |
| HLA-DRB1 | rs502055 | 0.00300 |
| HLA-DQA1 | rs9272723 | 0.00329 |
| LOC100294145 | rs9276915 | 0.00352 |
| C6orf10 | rs2894254 | 0.00372 |
| UBD | rs9368606 | 0.00403 |
| C6orf10 | rs3129900 | 0.00458 |
| MCCD1 | rs2734573 | 0.00553 |
| PRRC2A | rs1046080 | 0.00618 |
| C6orf10 | rs7767325 | 0.00623 |
| C6orf15 | rs2517448 | 0.00627 |
| C6orf10 | rs3132928 | 0.00640 |
| HLA-H | rs3132722 | 0.00675 |
| HLA-DQB2 | rs2857210 | 0.00685 |
| HLA-DRA | rs3129868 | 0.00731 |
| ATP6V1G2-DDX39B/DDX39B | rs933208 | 0.00740 |
| NFKBIL1 | rs2857605 | 0.00755 |
| TRIM26 | rs3132671 | 0.00757 |
| HLA-DQB1 | rs3129716 | 0.00770 |
| MSH5/MSH5-C6orf26 | rs3131379 | 0.00849 |
| MSH5/MSH5-C6orf26 | rs3130484 | 0.00901 |
| PSMB9 | rs9276832 | 0.00907 |
| BTNL2 | rs2213581 | 0.00922 |
| HLA-DMA | rs11539216 | 0.00929 |
| ATP6V1G2-DDX39B/DDX39B | rs3093978 | 0.00957 |
| C6orf10 | rs2143461 | 0.00986 |
| TUBB | rs3095330 | 0.00990 |
| LOC100294145 | rs4959119 | 0.00992 |
| TRIM26 | rs2517611 | 0.00993 |
|
| ||
| Anti-β 2GPI | ||
|
| ||
| HLA-DPB2 | rs9277916 | 0.00147 |
| HLA-DQA2 | rs9275793 | 0.00310 |
| HLA-DQA2 | rs9275765 | 0.00315 |
| HLA-DQA2 | rs9275772 | 0.00315 |
| HLA-DPA1 | rs3130182 | 0.00331 |
| HLA-DQB1 | rs9469220 | 0.00372 |
| HLA-DPB2 | rs4711314 | 0.00378 |
| HLA-DQA2 | rs2647089 | 0.00463 |
| HLA-DQA2 | rs9276298 | 0.00523 |
| HLA-DQB1 | rs9275356 | 0.00526 |
| HLA-DQA2 | rs17615250 | 0.00710 |
| HLA-DQA2 | rs9275618 | 0.00807 |
*ACL: anticardiolipin antibodies; LAC: lupus anticoagulant; Anti-β 2GPI: anti-β 2 glycoprotein I antibodies; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the SNP; SNP: single-nucleotide polymorphism; P: P-values for the test.