Table 3.

Incidence and HR of SSSI

Result	nbDMARD n=3673	All anti-TNF n=11881	Etanercept n=4139	Infliximab n=3475	Adalimumab n=4267
Follow-up (pyrs)	5416	17048	6122	4529	6397
SSSI events	39	269	120	79	67
SSSI incidence (/100 patient-years)	0.7 (0.5–1.0)	1.6 (1.4–1.8)	2.0 (1.6–2.3)	1.7 (1.4–2.2)	1.0 (0.8–1.3)
SSSI unadjusted HR	Ref	2.1 (1.5–3.0)	2.8 (1.9–4.0)	2.5 (1.7–3.7)	1.5 (1.0–2.2)
SSSI adjusted HR*	Ref	1.3 (0.8–2.2)	.5 (0.9–2.5)	1.5 (0.9–2.5)	1.1 (0.6–2.1)

^*Adjusted rates using propensity modelling described in the Methods section and using multiple imputations to replace missing baseline variables.

nbDMARD, non-biological disease-modifying antirheumatic drug; SSSI serious skin and soft tissue infections; TNF, tumour necrosis factor.