Table 4.

Incidence and HR of shingles

Result	nbDMARD n=3673	All TNF n=11 881	Etanercept n=4139	Infliximab n=3475	Adalimumab n=4267
Follow-up (patient-years)	5417	17 048	6122	4529	6397
Shingles events	45	275	99	91	85
Shingles incidence (/100 patient-years)	0.8 (0.6–1.1)	1.6 (1.4–1.8)	1.6 (1.3–2.0)	2.0 (1.6–2.5)	1.3 (1.1–1.6)
Shingles unadjusted HR	Ref	1.9 (1.4–2.6)	1.7 (1.2–2.5)	2.4 (1.7–3.4)	1.7 (1.2–2.5)
Shingles adjusted HR*	Ref	1.7 (1.1–2.7)	1.7 (1.0–2.7)	2.2 (1.4–3.4)	1.5 (0.9–2.4)

^*Adjusted rates using propensity modelling described in the Methods section and using multiple imputations to replace missing baseline variables.

nbDMARD, non-biological disease-modifying antirheumatic drug; TNF, tumour necrosis factor.