Fig. 2.

IRP2 and DMT1 expression are largely unchanged in stable MCI, progressive MCI as well as early AD subjects. Only DMT1-nonIRE, which is not controlled by IRP2, is slightly elevated in MCI subjects that were cognitively stable for at least five years (1.2 fold increase, p < 0.1). Cumulatively, these data suggests that the iron regulatory axis remained largely intact in lymphocytes of pre-dementia and early dementia patients. (For n see Table 1).