Figure 1.

Overview of the DACS Subnetworks.

Notes: The DACS Network is comprised of 34 submodels that represent relevant signaling within five areas of biology – apoptosis, autophagy, DNA damage response, necroptosis, and senescence. Each of the 34 submodels describes the molecular signaling mechanisms shown to activate or inhibit the end process (eg, in the submodel ‘Replicative senescence,’ increased CDKN2A and CDKN1A protein abundances lead to the induction of replicative senescence, while increased abundance of WRN protein inhibits replicative senescence). The left panel lists the names of the submodels involved in each area (eg, ‘Replicative senescence’ under Senescence), and the right panel shows an agglomerated diagram of all submodels involved in each area, with different submodels highlighted in unique colors.