Table S5.
Nodes from the transcriptional regulation of the senescence-associated secretory phenotype (SASP) submodel of the DACS Network that are predicted as HYPs by RCR on the GSE28464 test data set.
| Transcriptional Regulation of the SASP HYPs | Expected Direction | Test Data Set |
|---|---|---|
| GSE28464 | ||
| Predicted in consistent directions | ||
| CCL2 | ||
| CCL5 | ||
| CEBPB | ||
| CXCL1 | ||
| IFNG | ||
| IL1 Family Hs | ||
| IL6 * | ||
| IL13 | ||
| IL1A | ||
| IL8 | ||
| kaof(p38 MAPK family Hs) | ||
| NFKB Complex Hs | ||
| RELA | ||
| taof(CEBPB) | ||
| taof(NFKB Complex Hs) | ||
| VEGFA | ||
Notes: Expected direction is based on internal causality of the transcriptional regulation of the SASP submodel. Yellow = predicted increase in abundance or activity, blue = predicted decrease in abundance or activity. Submodel nodes that are shared with other senescence models are bolded.
IL6 is shown as predicted increased in this table, in contrast to the initial prediction by RCR (See Section 3.3 Application of the DACS Network to an Independent Data Set for additional detail and Supplementary Fig. 2).
Abbreviations: kaof(X), kinase activity of X; taof(X), transcriptional activity of X.