Table 2.
Nodes from the oncogene-induced senescence submodel of the DACS Network that are predicted as HYPs by RCR on the GSE28464 test data set.
| Oncogene Induced Senescence HYPs | Expected Direction | Test Data set |
|---|---|---|
| GSE28464 | ||
| Predicted in consistent directions | ||
| BNIP3L | ||
| cell aging | ||
| ETS2 | ||
| FOXO1 | ||
| gtpof(Ras family Hs) | ||
| HBP1 | ||
| HRAS | ||
| HRAS mutated at G12V | ||
| IFNG | ||
| IL1A | ||
| kaof(MAP2K1) | ||
| kaof(MAP2K6) | ||
| kaof(MEK Family Hs) | ||
| kaof(p38 MAPK family Hs) | ||
| kaof(RAF1) | ||
| LIF | ||
| MAP2K1 | ||
| MAP2K6 | ||
| MIF | ||
| Oncogene induced senescence | ||
| OSM | ||
| PPBP | ||
| RAF1 | ||
| RAS Family Hs | ||
| SMARCB1 | ||
| taof(ETS2) | ||
| taof(FOXO1) | ||
| VEGFA | ||
| Predicted in inconsistent directions | ||
| KRAS | ||
| KRAS mutated at G12V | ||
Notes: Expected direction is based on internal causality of the oncogene-induced senescence submodel. Yellow = predicted increase in abundance or activity; blue = predicted decrease in abundance or activity. Submodel nodes that are shared with other senescence models are bolded.
Abbreviations: gtpof(X), GTP-bound activity of X; kaof(X), kinase activity of X; taof(X), transcriptional activity of X.