Table 1. Genistein and daidzein levels in serum and urine.

Group	Dose (g/kg)	Genistein(ng/mL)		Daidzein(ng/mL)
		Serum	Urine	Serum	Urine
Group A	0	85 ± 166	4457 ± 6329	751 ± 751	79443 ± 130673
	6.25	24 ± 69	22230 ± 26478	243 ± 628	175729 ± 155494
	12.5	102 ± 58	50531 ± 28552	129 ± 129	544734 ± 288620
	25.0	1400 ± 1141	55053 ± 21808	3843 ± 3843	718022 ± 106312
Group B	0	0	0	0	0
	6.25	54 ± 47	63900 ± 17600	827 ± 530	744932 ± 97879
	12.5	73 ± 41	108421 ± 42254	1525 ±1222	890793 ± 292855
	25.0	105 ± 105	327938 ± 391396	1653 ± 594	1210856 ± 1132913
Group C	0	0	0	0	0
	6.25	231 ± 487	41698 ± 27517	1682 ± 1867	821262 ± 144547
	12.5	604 ± 787	150914 ± 38031	2688 ± 2013	902685 ± 183485
	25.0	2406 ± 1161	318376 ± 117520	5425 ± 1501	1345788 ± 323073

Group A: Mice were fed with the diet containing different doses of soy isoflavone extracts (at dietary concentrations of 0, 6.25, 12.5 and 25 g/kg, using genistein as standard) for two weeks, and then ovariectomized. After recovery, E2 patches (containing 0.6 mg estradiol) were placed on their backs for 7 d. One week later, MCF-7 cells were injected at 200 (µL (1×10⁷ cells/200 (µL) per site into the flanks of nude mice. The E2 patches were removed until the tumor surface area reached 10 mm².

Group B: Mice were first ovariectomized and then implanted with MCF-7 cells using the aforementioned method. The mice were fed with the diet containing different doses of isoflavone extracts (at dietary concentrations of 6.25, 12.5 and 25 g/kg) until the tumor surface area reached 10 mm². Group C: Mice were first implanted with MCF-7 cells and then fed with the diet containing different doses of soy isoflavone extracts (at dietary concentrations of 0, 6.25,12.5 and 25 g/kg).

(mean±SD)