Fig. 5.

Acute toxicity of VNI using Swiss female mice. Single doses were administered on day 1 (starting at 25 mg/kg up to 400 mg/kg – p.o.) and then mice were inspected up to 48 h for toxic and sub-toxic symptoms. (a) Mean ± SD values (n = 3) of three independent assays showing the percentage (%) of animal body weight variation (0–48 h posttreatment). (b) Mean ± SD values (n = 3) of three independent assays showing ratio values of organ weight/body weight measurements after 48 h of VNI administration; p < 0.05.