Table 1.
Biochemical analysis of blood samples from control and VNI-treated female mice (n = 3).
| VNI (mg/kg) | 0 | 25 | 50 | 100 | 200 | 400 |
|---|---|---|---|---|---|---|
| Red blood cells (million cells/mcL) | 8.73 ± 0.8 | 8.19 ± 0.7 | 8.59 ± 0.6 | 8.76 ± 0.8 | 8.69 ± 0.7 | 7.97 ± 0.7 |
| Hemoglobin (gm/dL) | 15 ± 1.4 | 13.7 ± 1.1 | 14.6 ± 1.2 | 14.2 ± 1.3 | 14.1 ± 1.1 | 13.4 ± 1.2 |
| Hematocrit (%) | 49.7 ± 4.1 | 45.8 ± 3.7 | 48.4 ± 3.6 | 49.0 ± 4.1 | 48.8 ± 3.9 | 45.6 ± 4.0 |
| Average red blood cell size (MCV – femtoliter) | 56.9 ± 4.9 | 55.9 ± 4.7 | 56.3 ± 5.0 | 55.9 ± 4.3 | 56.2 ± 4.5 | 57.2 ± 4.7 |
| Hemoglobin amount per red blood cell (MCH-pg/cell) | 17.2 ± 1.4 | 16.7 ± 1.5 | 17.0 ± 1.4 | 16.2 ± 1.5 | 16.2 ± 1.3 | 16.8 ± 1.3 |
| Amount of hemoglobin relative to the size of the cell (hemoglobin concentration) per red blood cell (MCHC-gm/dL) | 30.2 ± 2.7 | 29.9 ± 2.5 | 30.2 ± 3.0 | 29.0 ± 2.4 | 28.9 ± 2.4 | 29.4 ± 2.6 |
| White blood cell (WBC-cells/mcL) | 7.9 ± 0.7 | 9.6 ± 0.8 | 12.8 ± 1.1 | 13.3 ± 1.1 | 12.2 ± 1.0 | 9.4 ± 0.7 |
| Platelets | 1483 ± 118 | 1587 ± 127 | 1652 ± 139 | 1574 ± 126 | 1398 ± 110 | 1173 ± 95 |
| Naa | 156 ± 13 | 153 ± 13 | 152 ± 10 | 154 ± 11 | 152 ± 12 | 153 ± 11 |
| Ka | 9.5 ± 0.8 | 9.3 ± 0.7 | 7.9 ± 0.6 | 7.7 ± 0.6 | 8.0 ± 0.7 | 7.4 ± 0.7 |
| Cla | nd | 91 ± 7 | 92 ± 9 | 92 ± 8 | nd | nd |
| Pa | 13.7 ± 1.0 | 13.8 ± 1.1 | 12.8 ± 1.0 | 14.1 ± 1.4 | 13.2 ± 1.2 | 13.3 ± 0.9 |
| Glucosea | 199 ± 13 | 251 ± 19 | 211 ± 17 | 228 ± 15 | 262 ± 21 | 234 ± 18 |
| Alanine aminotransferase (ALT)a | 107 ± 7 | nd | 81 ± 6 | 78 ± 5 | 75 ± 6 | 82 ± 7 |
a
Reference values (CECAL/Fiocruz): Na (124–174), K (4.6–8), Cl (92–120), P (6.1–10.1), glucose (90–192) and ALT (up to 132).