Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Grade 3 to 4 nonhematologic toxicities
| Category | 10 mg/m2 (n = 3) |
20 mg/m2 (n = 3) |
40 mg/m2 (n = 6) |
56 mg/m2 (n = 6) |
140 mg (n = 6) |
|---|---|---|---|---|---|
| Cardiac: QTcF prolongation | 1/6a | ||||
| Gastrointestinal: mucositis | 1/6 | ||||
| Liver: hyperbilirubinemiab | 1/3 | 2/6 | 1/6 | ||
| Skin: hand–foot syndrome | 1/3 | 1/6c |
Plus 1 additional patient with transient (<30 minute) grade 3 QTcF > 500 milliseconds.
All grade 3 and resolved within 48 hours.
Prolonged (>7 days).
