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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Hum Genet. 2012 Dec 13;58(2):102–108. doi: 10.1038/jhg.2012.143

Figure 1.

Figure 1

Eight different pathogenic alleles of CLDN14 are associated with hearing loss in human. (a) Schematic of human claudin14. Topology of claudin14 was predicted by TMpred software. Yellow and blue amino acids indicate negatively and positively charged residues, respectively. The positions of eight residues mutated in all reported DFNB29 families are red. (b) Localization of claudin 14 in the apical bicellular tight junctions between the outer hair cells (OHCs) and Deiters’ cells (green). (c) Localization of claudin 14 (green) in the tight junctions between inner hair cells (IHCs) and pillar cells and between two adjacent pillar cells. Filamentous actin is highlighted by rhodamine-phalloidin (red). Scale bar is 5 μm.