Table 2.
Contribution of different genes to hearing loss in Pakistani families
| Gene | Locus | Percentage (fraction) of families |
95% CI | Reference |
|---|---|---|---|---|
| CLDN14 | DFNB29 | 2.25 (18/800) | 1.4 – 3.5 | [1, 25], this study |
| SLC26A4 | DFNB4/PDS | 7.23 (56/775) | 5.6 – 9.2 | [35, 36] |
| GJB2 | DFNB1 | 6.12 (12/196) | 3.5 – 10.4 | [37] |
| HGF | DFNB39 | 5.12 (41/800) | 3.8 – 6.8 | [38] |
| TMC1 | DFNB7/11 | 3.41 (19/557) | 2.2 – 5.3 | [39, 40] |
| MYO15A | DFNB3 | 3.33 (20/600) | 2.2 – 5.1 | [41, 42] |
| OTOF | DFNB9 | 2.33 (13/557) | 1.4 – 4.0 | [43] |
| TRIC | DFNB49 | 1.30 (11/841) | 0.7 – 2.3 | [28, 44] |
| TRIOBP | DFNB28 | 1.29 (10/775) | 0.7 – 2.3 | [45, 46] |
| ILDR1 | DFNB42 | 1.29 (11/850) | 0.7 – 2.3 | [47] |
| MYO6 | DFNB37 | 1.20 (3/250) | 0.4 – 3.4 | [48] |
| GIPC3 | DFNB72 | 0.75 (6/800) | 0.3 – 1.6 | [49] |
| TPRN | DFNB79 | 0.50 (4/800) | 0.2 – 1.2 | [50] |
| RDX | DFNB24 | 0.36 (2/557) | 0.1 – 1.2 | [51] |
CI: confidence interval.