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. 2012 Dec 7;14(2):191–198. doi: 10.1038/embor.2012.196

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Copyright © 2013, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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Location-independent activation of early origins in the VPS13 locus. Relative binding of Cdc45 to origins is shown. (A) VPS13-ARS305 and ARS305; (B) VPS13-ARS607 and ARS607; (C) VPS13-ARS737 and ARS737. The binding of Cdc45 to the origin-free VPS13 locus is shown for reference in all panels. Error bars indicate s.d. of three experiments. ARS, autonomously replicating sequence.