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. 2013 Mar 13;8(3):e58703. doi: 10.1371/journal.pone.0058703

Figure 1. The RSK inhibitor BI-D1870 inhibits the contractile response to high [K+] stimulation of intact rabbit pulmonary artery.

Figure 1

High [K+] (179 mM) stimulation was carried out in the presence of 25 nM, 100 nM and 1 µM BI-D1870 and on paired muscle strips the corresponding concentrations of the diluent DMSO were used as indicted. 1 µM BI-D1870 significantly inhibited both the phasic and tonic component of contraction.