Figure 2. Inhibition of ROCK does not inhibit the ability of the RSK inhibitor BI-D1870 to suppress the high [K⁺] contraction and BI-D1870 significantly suppresses U46619-induced force in intact pulmonary artery.

(A) Pretreatment of intact SM with the ROCK inhibitor, Y-27632 or Y-27632 plus BI-D1870 prior to stimulation with U46619. Force responses were normalized to the KCL-induced contraction taken as 100%. (B) Pretreatment of intact SM with 25 nM, 100 nM and 1 µM BI-D1870 prior to stimulation of U46619.