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. 2013 Mar 13;8(3):e59233. doi: 10.1371/journal.pone.0059233

Figure 3. Exogenous GGPP, but not FPP, reverses atorvastatin-mediated small GTPase translocation.

Figure 3

The Rho GTPases, including Rac1, RhoA and Cdc42 demonstrate translocation from the EC membrane to the cytosol in response to atorvastatin (5 µM, 16 h). This effect is consistent with inactivation of Rho GTPases at the cell membrane by atorvastatin, and is inhibited by MVA (100 µM, 16 h) and GGPP (10 µM, 16 h) but not FFP (10 µM, 16 h) implicating effects specific to geranylgeranylation inhibition. Data in shown in graphs represent the means ± S.E. for 4 samples for each treatment. Statistically significant differences between selected treatment groups were highlighted, * p<0.05; #P<0.01.