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. 2013 Mar 13;8(3):e57380. doi: 10.1371/journal.pone.0057380

Figure 6. Cerebral Mitochondrial Respiratory Chain Hyperfunction Abnormalities Were Corrected by Antipurinergic Therapy.

Figure 6

(A) Mitochondrial Respiratory Chain Complex I Enzymatic Activity was Increased 34% by gestational poly(IC) exposure and corrected by suramin treatment (Sal-Sal = 152+/−2.3 U/CS; PIC-Sal = 205+/−2.9 U/CS; one-way ANOVA F(3,12) = 137; p<0.0001; n = 4–5 males per group; age = 16 weeks). (B) Complex IV Activity was increased 53% by gestational poly(IC) exposure and corrected by suramin treatment (Sal-Sal = 0.319+/−0.045 U/CS; PIC-Sal = 0.492+/−0.018; one-way ANOVA F(3,12) = 8.9; p = 0.0022; n = 4–5 males per group; age = 16 weeks). Values are expressed as mean +/− SEM.