Figure 8. Cerebral Synaptosomal Hypophosphorylation of Extracellular Response Kinase 1 and 2 (ERK1/2), Calcium-Calmodulin Kinase II (CAMKII), and Downregulation Fragile X Protein (FMRP) in the MIA Model Were Corrected, and Nicotinic Acetylcholine Receptor subunit α7 (nAchRα7) Expression was Increased by Antipurinergic Therapy.

(A) Western analysis of phosphorylated ERK1/2 (pERK1/2^{Thr202/Tyr204}), total ERK1/2, phosphorylated CAMKII (pCAMKII^Thr286), total CAMKII (CAMKIIpan), FMRP (Fragile X Syndrome protein), Nicotinic Acetylcholine Receptor subunit α7 (nAchRα7), and PSD95 (post-synaptic density protein 95) was used as a loading control for synaptosomes. Each lane contains the synaptosomes from 2–3 males isolated at 16-weeks of age (n = 4–5 per group).