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. 2013 Mar 13;8(3):e57380. doi: 10.1371/journal.pone.0057380

Figure 9. Quantitative Analysis of the Extracellular Response Kinase 1 and 2 (ERK1/2), Calcium-Calmodulin Kinase II (CAMKII), Fragile X Protein (FMRP), and the Nicotinic Acetylcholine Receptor subunit α7 (nAchRα7) in Cerebral Synaptosomes in the MIA Model.

Figure 9

(A) ERK1 (MAPK3) and ERK2 (MAPK1) phosphorylation was decreased by over 90% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−5%; Sal-Sur = 6.2+/−0.8%; PIC-Sal = 9.9+/−2.6%; PIC-Sur = 84+/−2.3%; one-way ANOVA F(3,12) = 241; p<0.0001; n = 4–5 males per group; age = 16 weeks). (B) CAMKII phosphorylation was decreased by over 50% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−3%; Sal-Sur = 29+/−4.5%; PIC-Sal = 49+/−1.9%; PIC-Sur = 106+/−13%; one-way ANOVA F(3,12) = 25; p<0.0001; n = 4–5 males per group; age = 16 weeks). (C) Fragile X Mental Retardation Protein (FMRP) expression was decreased by over 40% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−8%; Sal-Sur = 56+/−1.2%; PIC-Sal = 55+/−2.5%; PIC-Sur = 89+/−6.5%; one-way ANOVA F(3,12) = 17.7; p<0.0001; n = 4–5 males per group; age = 16 weeks). (D) Nicotinic Acetylcholine Receptor subunit α7 (nAchRα7) expression was increased by over 75% by suramin treatment. (one-way ANOVA F(3,12) = 14.1; Sal-Sal = 100+/−9%; PIC-Sur = 176+/−18%; p<0.001; n = 4–5 males per group; age = 16 weeks; Newman-Keuls post test). Values are expressed as mean +/− SEM.