Table 1. Summary of Antipurinergic Therapy Results in the Poly(IC) Mouse Model of Autism Spectrum Disorders.
| Feature | Abnormality in Males | Response to Antipurinergic Therapy |
| Social Preference | Decreased | Normalized (p<0.05) |
| Sensorimotor Coordination (Rotarod) | Decreased | Normalized (p<0.001) |
| Basal Body Temperature | Decreased | Normalized (p<0.001) |
| Oxygen Consumption During Sleep | Unchanged* | Increased (p<0.001) |
| Plasma Immunoglobulins | Unchanged* | Increased (p<0.05) |
| Plasma Corticosterone | Unchanged* | Increased (p<0.03) |
| Synaptosomal Structure by Electron Microscopy | Fragile and malformed post-synaptic densities; Accumulation of electron dense material | Normalized |
| Cerebral Mitochondrial Respiratory Chain Complex I Activity | Increased | Normalized (p<0.02) |
| Cerebral Mitochondrial Respiratory Chain Complex IV Activity | Increased | Normalized (p<0.02) |
| Synaptosomal Purinergic Receptor (P2Y2) Expression | Decreased | Normalized (p<0.02) |
| Synaptosomal Purinergic Receptor (P2X7) Expression | Decreased | Normalized (p<0.02) |
| Synaptosomal ERK1/2 Phosphorylation | Decreased | Normalized (p<0.001) |
| Synaptosomal CAMKII Phosphorylation | Decreased | Normalized (p<0.001) |
| Synaptosomal FMRP Expression | Decreased | Normalized (p<0.02) |
| Synaptosomal Nictotinic Acetylcholine Receptor subunit α7 Expression | Unchanged* | Increased (p<0.001) |
| Cerebellar Vermis Lobule VII Purkinje Cell Number | Decreased | Preserved (p<0.05) |
*
Unchanged at 4 months of age in the sham-treated poly(IC) mice, but increased therapeutically by suramin.