Table 1. Selectivity of Tripolins against a panel of kinases.
IC50 values (µM) | ||
Kinase analyzed | Tripolin A | Tripolin B |
Aurora A | 1.5 | 2.5 |
Aurora B | 7.0 | 6.0 |
EGFR | 11.0 | 71.7 |
FGFR | 33.4 | 38.0 |
KDR | 17.9 | 6.5 |
IGF1R | 14.9 | 13.2 |
IC50 values of Tripolin A and Tripolin B against Aurora A, Aurora B and a panel of other selected kinases.