Table 1. Growth parameters of control and STZ-treated embryos at E14.5; and control, STZ and STZ+Insulin-treated embryos at E18.5.

			Bodyweight (mg)	Crown-Rump Length (mm)	Head width (mm)	Placenta weight (mg)
E14.5	Control	Male	280.3±15.7	11.9 ±0.3	7.1±0.2	118.8±5.5
		Female	261.1±15.8	11.8±0.3	7.0±0.2	111.6±5.6
	STZ	Male	189.9±15.9	10.5±0.3	6.4±0.2	79.9±5.7
		Female	180.1 ±16.1	10.4±0.3	6.3±0.2	71.0±5.8
	P treatment		0.004	0.004	0.01	0.001
	P sex		0.008	0.32	0.58	0.02
	P treatment*sex		0.38	0.87	0.63	0.79
E18.5	Control	Male	1169.7±32.0	20.9±0.5	10.8±0.2	112.6±5.5
		Female	1184.4±33.7	21.0±0.5	10.9±0.2	108.7±5.6
	STZ	Male	748.7±37.8	16.8±0.5	9.3±0.2	72.9±6.3
		Female	727.7±40.3	16.6±0.6	9.4±0.2	61.4±7.0
	STZ+Insulin	Male	752.3±48.9	17.0±0.7	10.0±0.3	80.3±8.3
		Female	713.7±55.4	16.2±0.8	9.6±0.3	69.7±9.0
	P treatment		<0.0001	<0.0001	<0.0001	<0.0001
	P sex		0.54	0.12	0.50	0.04
	P treatment*sex		0.61	0.19	0.27	0.62

Data from E14.5 and E18.5 cohorts were analysed separately by a linear mixed model with maternal STZ and insulin treatment and offspring sex as independent variables, weighted for litter. Values are mean±SEM. E14.5: (n)  =  control (n =  5 litters comprising 41 embryos), STZ-treated (n = 5 litters comprising 33 embryos). E18.5: (n)  =  control (n = 11 litters comprising 72 embryos), STZ (n = 10 litters comprising 41 embryos), STZ+Insulin (n = 5 litters comprising 25 embryos).