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. 2013 Mar 13;8(3):e58156. doi: 10.1371/journal.pone.0058156

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© 2013 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) ABR measurement results of 14 week old Mcph1^tm1a/tm1a mice (n = 11) in MGP showed mild to moderate hearing impairment, or normal hearing compared to control mice. The green baseline area shows a reference range for the control wild type mice with the same genetic background, plotting the median and 2.5 to 97.5 percentile of the population (n = 440). (B) Input-output function (IOF) analysis. The peak-peak amplitude of wave 1 (P1-N1 amplitude) of click-evoked ABRs is plotted as a function of dB SL (Sensation Level, dB above threshold) for wild type (green) and Mcph1^tm1a/tm1a (red) mice. There was no significant difference of IOF slopes of Mcph1^tm1a/tm1a (n = 24, slope = 0.144+/−0.066; mean +/− SD) and wild type mice (n = 36, slope = 0.133+/−0.048) (t-test, p = 0.444).