Figure 8. Mcph1^{tm1a /tm1a} mice have normal skull structure but smaller skull size.

(A) X-ray assay showed comparable structure of craniofacial skeleton between wild type and Mcph1^{tm1a /tm1a} mice at 14 weeks old. (B) Measurement showed that skull width and length in female Mcph1^{tm1a /tm1a} mice (n = 6) are significantly smaller than those of wild type mice (n = 7) (Rank Sum test). The weight of the brain was measured at 16 weeks of age showed that female and male Mcph1^{tm1a /tm1a} mice (n = 3, each sex) had lighter brain than the local control mice (n = 3, each sex) and MGP wild type mouse baseline (female, n = 10; male n = 187).