Table 1.
Characteristics of participants in the Non-Hodgkin Lymphoma nested case-control study within the Multiethnic Cohort (MEC)
| Characteristics | Casesa | Controlsa | p-valueb | MECc |
|---|---|---|---|---|
| N | 272 | 541 | 203,621 | |
| Age at blood draw, yd | 70.0 ± 7.4 | 70.0 ± 7.5 | ||
| Fasting prior to blood draw, hrs d | 12.0 ± 4.0 | 12.3 ± 4.1 | ||
| Maled | 157 (58) | 313 (58) | 91,905 (45) | |
| Ethnicityd | ||||
| White | 74 (27) | 148 (27) | 49,604 (24) | |
| Japanese American | 72 (27) | 143 (27) | 57,011 (28) | |
| Latino | 62 (23) | 123 (23) | 47,516 (24) | |
| African American | 47 (17) | 94 (17) | 34,971 (17) | |
| Native Hawaiian | 17 (6) | 33 (6) | 14,519 (7) | |
| BMI, kg/m2 | 27.0 ± 5.4 | 26.4 ± 4.4 | 0.11 | 26.1±5.1 |
| Overweight (25.0–29.9 kg/m2) | 106 (39) | 219 (40) | 72,739 (36) | |
| Obese (≥30.0 kg/m2) | 57 (21) | 96 (18) | 34,515 (17) | |
| Secondary or higher education | 182 (67) | 345 (64) | 0.39 | 110, 471 (55) |
| Alcohol intake ≥1 drink/month | 137 (50) | 284 (53) | 0.57 | 114,129 (56) |
| Ever smoker | 164 (60) | 291 (54) | 0.08 | 112,185 (55) |
| Pack-years of cigarette smoking | 10.4 ±15.1 | 9.8 ± 15.2 | 0.55 | 10.1±15.0 |
| Diabetes, self-reported | 36 (13) | 22 (4) | <0.001 | 24,342 (12) |
| Circulating inflammatory markers | ||||
| Adiponectin, μg/mL | 7.4 (4.4–13.7) | 7.8 (4.7–13.0) | 0.71 | |
| Leptin, ng/mL | 8.5 (3.8–17.1) | 10.6 (5.2–21.8) | <0.01 | |
| IFN-γ, pg/mL | 0.7 (0.3–1.2) | 0.6 (0.4–1.0) | 0.97 | |
| IL-1β, pg/mL | 1.1 (0.5–2.5) | 1.0 (0.5–2.1) | 0.38 | |
| IL-2, pg/mL | 1.3 (0.7–2.5) | 1.3 (0.7–2.3) | 0.39 | |
| IL-4, pg/mL | 2.3 (1.2–4.1) | 2.3 (1.1–4.2) | 0.62 | |
| IL-5, pg/mL | 0.6 (0.3–1.2) | 0.6 (0.3–1.1) | 0.41 | |
| IL-6, pg/mL | 1.9 (0.9–4.1) | 1.6 (0.9–3.42 | 0.13 | |
| IL-8, pg/mL | 10.5 (5.9–20.3) | 9.2 (5.3–17.9) | 0.10 | |
| IL-10, pg/mL | 1.4 (0.6–3.0) | 0.9 (0.5–1.7) | <0.001 | |
| TNF-α, pg/mL | 2.6 (1.4–6.5) | 2.6 (1.2–5.9) | 0.41 | |
| CRP, mg/L | 1.9 (0.6–4.7) | 1.8 (0.7–4.3) | 0.61 | |
| Summary measuree | −0.2 (−0.6–0.3) | −0.6 (−0.2–0.3) | 0.49 | |
Abbreviations: BMI, body mass index; IFN, Interferon; IL, Interleukin; TNF, Tumor neurosis factor; CRP, C-reactive protein.
Values are mean ± SD, n (%) or median (25th–75th percentile). Data were missing for fasting hours (8), education (4), alcohol (17), leptin (1), CRP (3) among NHL cases and controls and for BMI (2,853) and secondary or higher education (2,437) in MEC.
p-values from χ2 test, Students t-test, or Wilcoxon rank sum test.
Comparison based on entire MEC data set excluding “Other” ethnicity (N=203,621)
Matching criteria.
Composite score from principal components analysis of log-transformed IL-1β, IL-4, IL-5, IL-6, IL-8, and TNF-α.