Table 4.

Risk of Non-Hodgkin Lymphoma by years between blood draw and diagnosis^a

	<2.7 years		2.7 years		pinteraction b
	Cases/controls	OR (95% CI)	Cases/controls	OR (95% CI)
Leptin, ng/ml					<0.0001
<6.4	51/80	1.00	54/86	1.00
6.4–<14.9	52/100	0.64 (0.36–1.15)	39/82	0.69 (0.39–1.23)
≥14.9	33/97	0.38 (0.19–0.74)	43/95	0.65 (0.33–1.27)
Ptrend c		<0.01		0.09
IL-10, pg/mL
<0.6	26/97	1.00	42/100	1.00	0.92
0.6<1.6	35/92	1.59 (0.83–3.06)	42/102	0.95 (0.52–1.72)
≥1.6	75/89	3.88 (2.08–7.26)	52/61	1.97 (1.07–3.62)
Ptrend c		<0.001		0.21

Abbreviations: BMI, body mass index; CI, Confidence interval; CRP, C-reactive protein IFN, Interferon; IL, Interleukin; OR, odds ratio; TNF, Tumor neurosis factor.

^aOR and 95% CI estimated by conditional logistic regression; cases and controls matched on sex, birthdate (± 1 year), ethnicity (white, Japanese American, Latino, African American, or Native Hawaiian), location (California or Hawaii), date of blood draw (within ±1 year), time of day of blood draw, and fasting hours prior to blood draw(0–<6, 6–<8, 8–<10, or ≥10). Data were missing for leptin (1).

^bp_interaction based on the Wald χ² test of cross-product terms between the log-transformed continuous serum measure and years between blood draw and diagnosis.

^cp_trend based on the Wald χ² test of a log-transformed continuous variable.