Figure 3.

Association between low levels of DNA methylation [below the cutoff of 4.74% mCyt/(mCyt+Cyt)] and cancer history estimated by means of unadjusted and adjusted Odds Ratio (ORs). The table under the Figure indicates the number of subjects with history of cancer (prevalent cancer subjects) and of controls with corresponding percentages indicated in parentheses.

* the adjusted Odds Ratio analysis was performed by multivariate logistic regression model that simultaneously controlled for sex, age, smoking habit, serum concentrations of inflammatory marker high-sensitivity C-reactive protein, plasma levels of folate, vitamin B12 and plasma total homocysteine.