Table 1.
Baseline characteristics of individuals included in the meta-analysis of IgE stratified by study.
| Study Cohort | |||||||
|---|---|---|---|---|---|---|---|
| SAPPHIRE (n=276) |
GRAAD-AC (n=635) |
GRAAD-AA (n=806) |
GALA (n=215) |
CAMP (n=362) |
CARE (n=229) |
STAMPEED (n=1,769) |
|
| Age in years – mean ± SD (range) | 30.4 ± 10.5 (12–56) | 28.3 ± 16.4 (3–84) | 29.5 ± 18.3 (4–78) | 12.9 ± 5.5 (8–35) | 8.8 ± 2.1 (5–13) | 6.0 ± 4.1 (1–17) | 30.9 ± 14.7 (6–81) |
| Female – no. (%) | 216 (78.3) | 322 (50.7) | 405 (50.2) | 90 (41.9) | 134 (37.0) | 59 (25.8) | 1,199 (67.8) |
| Race-ethnicity – no. (%) | |||||||
| African American | 276 (100) | 0 (0) | 806 (100) | 0 (0) | 0 (0) | 0 (0) | 752 (42.5) |
| African Caribbean | 0 (0) | 635 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| European American | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 362 (100) | 185 (80.8) | 1,017 (57.5) |
| Latino | 0 (0) | 0 (0) | 0 (0) | 215 (100) | 0 (0) | 44 (19.2) | 0 (0) |
| History of Asthma – no. (%) | 149 (54.0) | 274 (43.2) | 458 (56.8) | 215 (100) | 362 (100) | 229 (100) | 1,067 (60.3) |
| Serum total IgE (IU/ml) – geometric mean ± geometric SD | 103.5 ± 4.1 | 188.7 ± 4.8 | 90.9 ± 5.0 | 247.2 ± 3.9 | 428.4 ± 4.6 | 34.1 ± 4.1 | 94.6 ± 4.8 |
SAPPHIRE denotes Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity; GRAAD-AC, Genetic Research on Asthma in the African Diaspora-African Caribbean; GRAAD-AA, Genetic Research on Asthma in the African Diaspora-African American; GALA, Genetics of Asthma in Latino Americans; CAMP, Childhood Asthma Management Program; CARE, Childhood Asthma Research and Education Network; STAMPEED, SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data; SD, standard deviation; IgE, immunoglobulin E; and IU/ml, international units per milliliter.
STAMPEED comprises the Chicago Asthma Genetics Study (CAG), the National Heart, Lung, and Blood Institute Collaborative Studies of the Genetics of Asthma (CSGA), and the Severe Asthma Research Program (SARP).