Table 4.
Replication results for genome wide meta-analysis of serum total IgE levels stratified by race-ethnic group.*
| SNP | Chromosome | Nearest gene |
P-value | ||||
|---|---|---|---|---|---|---|---|
| European American (n=1,329) |
African Caribbean and African American (n=2,961) |
Latino (n=1,477) |
All groups – replication set (n=5,767) |
All groups – discovery and replication set combined† (n=10,059) |
|||
| rs321588 | 1 | PTBP2 | 0.4129 | 0.8124 | 0.3737 | 0.9062 | 0.0011 |
| rs2363709 | 3 | SUCLG2 | 0.5518 | 0.8460 | 0.0093 | 0.1896 | 4.55 × 10−6 |
| rs13361473 | 5 | MAT2B | 0.6795 | 0.2455 | 0.6848 | 0.4083 | 0.0002 |
| rs9469220 | 6 | HLA-DQB1 | 0.0592 | 0.1084 | 0.2255 | 0.0074 | 2.45 × 10−7 |
| rs10944017 | 6 | TBX18 | --‡ | 0.7110 | 0.9087 | 0.8132 | 0.0003 |
| rs7751374 | 6 | SOBP | 0.6858 | 0.5180 | 0.0550 | 0.7589 | 0.0006 |
| rs10124954 | 9 | TLE4 | 0.1098 | 0.5325 | 0.5034 | 0.5516 | 0.0044 |
| rs537526 | 11 | CCDC82 | 0.3519 | 0.6422 | 0.4353 | 0.7894 | 0.0022 |
| rs6499255 | 16 | WWP2 | 0.9524 | 0.1110 | 0.0308 | 0.0230 | 1.16 × 10−6 |
| rs16977747 | 17 | LINC00469 | --‡ | 0.0865 | 0.0373 | 0.8508 | 0.0031 |
The replication set included the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) (i.e., those not in the discovery set), the Study of African Americans, Asthma, Genes & Environments (SAGE - United States), the Gene-Environments and Admixture in Latino Americans cohort (GALA 2), the Study of Asthma Genes and the Environment (SAGE - Canada); the Canadian Asthma Primary Prevention Study (CAPPS), and the Hutterites.
The discovery set included the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE), Genetic Research on Asthma in the African Diaspora-African Caribbean (GRAAD-AC), the Genetic Research on Asthma in the African Diaspora-African American (GRAAD-AA), the Genetics of Asthma in Latino Americans (GALA), Childhood Asthma Management Program (CAMP), the Childhood Asthma Research and Education Network (CARE); the Chicago Asthma Genetics Study (CAG), the National Heart, Lung, and Blood Institute Collaborative Studies of the Genetics of Asthma (CSGA), and the Severe Asthma Research Program (SARP).
These SNPs were uninformative based on our within group threshold requiring a minor allele frequency ≥5%.