Table 5.
Replication results from earlier genome wide association studies for serum total IgE levels in the current meta-analytic group stratified by race-ethnicity.*
| Gene | SNP | Chromosome | Position | Alleles† | Risk Allele‡ |
P-value | |||
|---|---|---|---|---|---|---|---|---|---|
| European American (n=1,564) |
African Caribbean and African American (n = 2,469) |
Latino (n = 259) |
All groups combined (n=4,292) |
||||||
| DARC | rs13962¶ | 1 | 159175527 | G/A | G | 0.0019 | -- | 0.0590 | 0.0003 |
| FCER1A | rs2427837§** | 1 | 159258545 | G/A | -- | -- | -- | -- | -- |
| rs2494264¶ | 1 | 159266838 | T/A | T | 0.0115 | 0.3614 | 0.1527 | 0.2345 | |
| rs2251746§¶ | 1 | 159272060 | T/C | T | 0.0039 | 0.6669 | 0.0123 | 0.0072 | |
| rs2252226‖ | 1 | 159276153 | C/T | C | 0.0060 | 0.3452 | 0.1306 | 0.0060 | |
| rs4656784¶** | 1 | 159326880 | A/G | -- | -- | -- | -- | -- | |
| RAD50 | rs2706347§ | 5 | 131905117 | G/T | T | 0.0121 | 0.0301 | 0.0792 | 0.0064 |
| rs3798135§ | 5 | 131965109 | C/T | T | 0.0127 | 0.0002 | 0.1158 | 8.38 × 10−5 | |
| rs2040704§ | 5 | 131973177 | A/G | G | 0.0084 | 0.0039 | 0.1076 | 0.0007 | |
| rs7737470§ | 5 | 131974063 | T/A | A | 0.0094 | 0.1311 | 0.0929 | 0.0214 | |
| IL13 | rs20541‖¶ | 5 | 131995964 | A/G | A | 0.0003 | 0.8945 | 0.5571 | 0.0246 |
| rs2243297¶** | 5 | 131999171 | T/A | -- | -- | -- | -- | -- | |
| HLA-G | rs2523809¶ | 6 | 29849619 | G/T | T | 0.5319 | 0.9972 | 0.2351 | 0.4701 |
| HLA-A | rs2517754¶** | 6 | 29896680 | T/C | -- | -- | -- | -- | -- |
| rs2571391¶ | 6 | 29923838 | A/C | A | 0.4381 | 0.5206 | 0.5674 | 0.2730 | |
| HLA-DRB1 | rs9271300‖** | 6 | 32581582 | C/G | -- | -- | -- | -- | -- |
| HLA-DQA2 | rs2858331¶ | 6 | 32681277 | A/G | G | 0.0014 | 0.0102 | 0.0099 | 6.30 × 10−6 |
| STAT6 | rs167769‖¶ | 12 | 57503775 | C/T | T | 0.0574 | 8.81 × 10−5 | 0.6933 | 2.48 × 10−5 |
| rs12368672§ | 12 | 57512470 | C/G | G | 0.0357 | 0.0255 | 0.7028 | 0.0022 | |
| IL4R/IL21R | rs1859308‖ | 16 | 27397998 | A/G | A | 0.6262 | 0.1098 | 0.4543 | 0.2186 |
Includes the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE), the Genetic Research on Asthma in the African Diaspora-African Caribbean (GRAAD-AC) study, the Genetic Research on Asthma in the African Diaspora-African American (GRAAD-AA) study, the Genetics of Asthma in Latino Americans (GALA) study; the Childhood Asthma Management Program (CAMP), the Childhood Asthma Research and Education Network (CARE); the Chicago Asthma Genetics (CAG) study, the National Heart, Lung, and Blood Institute Collaborative Studies of the Genetics of Asthma (CSGA), and the Severe Asthma Research Program (SARP). Associations were first assessed in groups stratified by race-ethnicity, asthma status, and study before meta-analytically combining to generate the overall and population group results.
The first allele corresponds to the “reference/other” allele in dbSNP build 125.
The risk allele denotes the allele associated with high serum total IgE levels for all groups combined.
Identified by Weidinger et al.(4)
Identified by Moffatt et al.(6)
Identified by Granada et al.(47)
Not imputed