Figure 4.

Folding of the SHR-NTD. The NTD exists has an ensemble of conformations, having more or less stable structure (middle molecule). A more stably folded conformation of the NTD can be induced or selected by small molecules (osmolytes), posttranslational modification (e.g., phosphorylation), DNA binding, and interactions with coregulatory proteins. In these models of NTD folding, the more stable structure is shown to be α-helical by the solid cylinders (blue).