Table 4. Genotype and frequencies of five tSNPs in TGF-β1 gene among the CWP cases and controls and the associations with risk of CWP.
| No. | SNP ID | Genotype | Case |
Control |
P | OR (95% CI) | Adjusted OR (95% CI)a |
| [n(%)] | [n(%)] | ||||||
| 1 | rs1800469 | C > T | |||||
| CC | 114(22.44) | 102(19.39) | 1.00 | 1.00 | |||
| TC | 273(53.74) | 302(57.41) | 0.363 | 0.81(0.59-1.11) | 0.86(0.62-1.19) | ||
| TT | 121(23.82) | 122(23.19) | 0.713 | 0.89(0.62-1.28) | 0.93(0.64-1.36) | ||
| P | 0.402 | ||||||
| 2 | rs1800470 | T > C | |||||
| TT | 123(24.21) | 109(20.72) | 1.00 | 1.00 | |||
| TC | 338(66.54) | 332(63.12) | 0.511 | 0.90(0.67-1.22) | 0.90(0.66-1.23) | ||
| CC | 47(9.25) | 85(16.16) | 0.002 | 0.49(0.32-0.76) | 0.50(0.32-0.78) | ||
| P | 0.003 | ||||||
| 3 | rs2241716 | G > A | |||||
| GG | 219(43.11) | 224(42.58) | 1.00 | 1.00 | |||
| GA | 212(41.73) | 223(42.40) | 0.868 | 0.97(0.75-1.27) | 0.98(0.75-1.28) | ||
| AA | 77(15.16) | 79(15.02) | 0.507 | 1.00(0.69-1.44) | 0.88(0.61-1.28) | ||
| P | 0.977 | ||||||
| 4 | rs4803455 | C > A | |||||
| CC | 453(89.17) | 476(90.49) | 1.00 | 1.00 | |||
| CA | 55(10.83) | 50(9.51) | 0.509 | 1.16(0.77-1.73) | 1.15(0.76-1.75) | ||
| P | 0.482 | ||||||
| 5 | rs11466345 | A > G | |||||
| AA | 230(45.28) | 266(50.57) | 1.00 | 1.00 | |||
| AG | 225(43.54) | 229(43.54) | 0.594 | 1.14(0.88-1.47) | 1.02(0.75-1.40) | ||
| GG | 53(10.43) | 31(5.89) | 0.001 | 1.98(1.23-3.19) | 2.24(1.37-3.68) | ||
| P | 0.017 |
aAdjusted for age, smoking and exposure period.