Fig. 4.

β-catenin mutations in fundic gland polyp and heterotopic gastric mucosa in duodenum. In case 1, two 1-bp missense mutations at codon 32 (GAC to GAA resulting in the replacement of aspartic acid by glutamic acid), and codon 37 (TCT to CCT resulting in the replacement of serine by proline) were identified in the fundic gland polyp of the stomach. The same 1-bp missense mutation at codon 37 was identified in the heterotopic gastric mucosa (case 1). In case 2, a 1-bp missense mutation at codon 32, resulting in the replacement of aspartic acid by glutamic acid, was identified in the heterotopic gastric mucosa, while no mutation was observed in the fundic gland polyp of the stomach (case 2). In case 3, a 1-bp silent mutation at codon 33 was identified in the heterotopic gastric mucosa. In cases 1 and 2, DNA sequences were read in an antisense direction.