Figure 2.

Effect of ramosetron and ondansetron on changes in body weight and diarrhoea during the course of 5-FU treatment in mice. Animals were administered 5-FU (50 mg·kg⁻¹, i.p.) once daily for 5 days (days 0–4). Ramosetron (RAM, 0.01, 0.03, and 0.1 mg·kg⁻¹) and ondansetron (OND, 5 mg·kg⁻¹) were administered p.o. twice daily for 5 days. Body weight was monitored daily and is shown as a percentage of initial body weight (A), whereas severity of diarrhoea was scored daily using the four-grade scale (0 to 3), described in the Methods (B). Data are presented as the means ± SEM from six mice. Significant differences at P < 0.05; *from control (C, vehicle alone); ^#from normal (N, 5-FU-untreated).