Figure 3.

Effect of ramosetron and ondansetron on the shortening of intestinal villus height induced by 5-FU in mice. Animals were administered 5-FU (50 mg·kg⁻¹, i.p.) once daily for 5 days (days 0 to 4) and killed 5 days after the initiation of 5-FU treatment (day 5). Ramosetron (RAM, 0.01, 0.03 and 0.1 mg·kg⁻¹) and ondansetron (OND, 5 mg·kg⁻¹) were administered p.o. twice daily for 5 days. Haematoxylin and eosin staining was performed (A, 100×), and the heights of the intestinal villi were measured (from the top of the villus to the villus–crypt junction) by light microscopy (B). Data are presented as the means ± SEM from six mice. Significant differences at P < 0.05; *From control (C, vehicle alone); ^#from normal (N, 5-FU-untreated).