Figure 10.

Effect of ramosetron on the anti-tumour action and body weight loss induced by 5-FU in tumour-implanted mice. A Colon 38 tumour fragment (8 mm³) was implanted into the abdominal region of mice and the volume (mm³) of the Colon 38 solid tumour was measured every 2 days, starting 7 days after implantation. The animals were administered 5-FU (20 mg·kg⁻¹, i.p.) once daily for 5 days, and then administered 5-FU once daily for 5 days after a 2-day no-treatment period. Ramosetron (RAM, 0.1 mg·kg⁻¹) was administered p.o. twice daily for 14 days, starting 7 days after implantation. The tumour volume (A) and body weight (B) were measured every 2 days, starting 7 days after the implantation. Data are presented as the means ± SEM from six mice. N, vehicle alone (5-FU-untreated); C, vehicle + 5-FU; RAM, ramosetron + 5-FU; RAM alone, ramosetron alone (5-FU-untreated). #Significant difference from normal (N) at P < 0.05.