Table 1.
Pharmacological parameters of TLR4 stimulation by LPS alone and with different concentrations of LPS antagonist (RS) co-treatment
| Treatmenta | EC50b | 95% CI | Emax | 95% CI |
|---|---|---|---|---|
| LPS alone | 0.64 | 0.38–1.07 | 1.22 | 1.14–1.30 |
| LPS + RS (0.01) | 0.70 | 0.37–1.31 | 1.10 | 1.02–1.19 |
| LPS + RS (0.1) | 0.68 | 0.40–1.16 | 1.14 | 1.06–1.21 |
| LPS + RS (1.0) | 0.97 | 0.60–1.57 | 1.16 | 1.08–1.23 |
| LPS + RS (10) | 3.60* | 2.36–5.48 | 1.14 | 1.07–1.21 |
| LPS + RS (100) | 13.58* | 10.34–17.70 | 1.11 | 1.06–1.17 |
a
The LPS antagonist co-treatment concentrations with RS are given as ng·mL−1 in parenthesis.
b
Effective concentration for 50% TLR4 signalling, given in ng·mL−1.
*
denotes significantly different from LPS alone concentration–response curve.