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. 2013 Feb 25;168(6):1430–1444. doi: 10.1111/bph.12029

Figure 7.

Figure 7

PPARα-mediated activation of TRPV1 channels by CLO and PEA, but not by CAP. Representative whole-cell current traces evoked in the same TRPV1-expressing CHO cell showing the effect of the PPARα antagonist GW-6471 (10 μM) on TRPV1 currents elicited by CAP (5 μM) (A), CLO (100 μM) (B), and PEA (10 μM) (C). CHO cells were held at −60 mV; the bars on top of each panel represent the duration of GW-6471 exposure; in each panel, the arrow indicates the addition of the agonist (exposure time: about 3 s). (D) Quantification of the effects of GW-6471 (10 μM) and of CPZ (3 μM) on CAP-, CLO-, and PEA-evoked peak TRPV1 currents. Each point is the mean±S.E.M. of 8–16 determinations for each agonist.