Figure 9.

Exposure to sub-effective PEA concentrations reduce CAP-induced TRPV1 currents. Representative whole-cell current traces recorded in TRPV1-expressing CHO cells held at −60 mV in response to two subsequent 3 s exposures to 0.5 μM CAP, separated by a 1 min interval. The second CAP exposure was performed in control condition (n = 4; A), or upon pre-incubation with 0.01 μM PEA for 1 min (n = 12; B). The bars on the top of each trace correspond to the duration of drug exposures. Each trace is from a single cell, representative of the entire population. The percentage of current decrease induced by PEA exposure is indicated.